Immune system molecule affects our weight

ScienceDaily (Sep. 24, 2012) ? Researchers at the Sahlgrenska Academy, University of Gothenburg, Sweden, have identified a molecule in the immune system that could affect hunger and satiety. The researchers hope that new treatments for obesity will benefit from this finding.

Interleukin-6 is a chemical messenger in our immune system that plays an important role in fighting off infection. However, recent research has, surprisingly, shown that it can also trigger weight loss. Researchers at Sahlgrenska Academy, University of Gothenburg, have been investigating and managed to identify the specific types of brain cells that are targeted by the interleukin-6 molecule.

The results show that the cells that are affected by interleukin-6 produce substances that not only affect our sense of hunger and fullness but also control the body's ability to burn fat. "Interleukin-6 increases levels of substances in the brain that trigger weight loss, which could explain why high levels of this molecule lead to weight loss," says doctoral student Erik Sch?le, who is presenting the results in his thesis.

It is known that our normally low levels of interleukin-6 in the brain increase dramatically during an infection, typically accompanied by reduced hunger and fatigue.

"Our previous findings would indicate that interleukin-6 can play a key role in regulating the metabolism of healthy individuals too," says Erik Sch?le.

"This is clearly substantiated by our finding that mice which lack interleukin-6 get fat, and that the metabolism of rats injected with interleukin-6 directly into the brain increases."

Although it is not yet fully understood how interleukin-6 in the brain affects bodyweight, the researchers have concluded that anyone whose brain produces plenty of interleukin-6 could be protected against overweight. The thesis also shows that our gut bacteria indirectly affect the substances in the brain that regulate bodyweight.

"This is both surprising and new. It could in the long run lead to people fighting obesity by changing what they eat in line with how it affects the brain," says Erik Sch?le.

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Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/~3/kLNOIAsttL4/120924080257.htm

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Father of four killed after card game, gunman is sentenced - 620 WTMJ

RACINE, Wis. - Tension during a game of cards in Racine led one player to leave and return with a gun.

Now, the gunman, 28 year old Jeremiah Brown has been sentenced to 20 years in prison after pleading guilty to second degree reckless homicide while armed.

At his sentencing hearing Friday, Brown apologized to the victim's family, saying he told responsibility for this "senseless act."??

Thirty-four-year-old Terrell Byers was killed.

?A Journal Times of Racine report indicates Byers is survived by four children.

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Source: http://www.620wtmj.com/news/local/170839511.html

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PUHI: Community garage sale at Kauai Self Storage. Sat. 9/29, 8am-1 pm. Buyers and sellers welcome. Call 241-1465 to reserve space.

Sorry, Readability was unable to parse this page for content.

Source: http://kauai-www2.kauaiworld.com/mobile-classified/ads/29050173/?market=admarket

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Fiona Apple Makes Bizarre Statement After Arrest

Just days after getting arrested at a border stop for hashish possession, singer-songwriter Fiona Apple hit the stage for a concert in Houston where she made quite the confusing statement.

Now, most of the people were very nice to me. There are four of you out there, and I want you to know that I heard everything you did. I wrote it all down with your names and everything you did and said stupidly thinking that I couldn't hear or see you.

As the crowd cheered, the star went on to say she then ripped the paper up, but not before encoding it and getting two lock boxes, which she's calling "holding cell one" and "holding cell two." And she didn't stop there.

I'm the only one who holds the key, and you and I will be intimate forever because I will hold that secret forever. Unless of course the celebrity that you had so much interest in but you wanted to accuse me of bringing up while you laughed at me all night?

Apple, 35, was apprehended with undisclosed amounts of hashish on her tour bus, and was being held at Hudspeth County Jail. Sierra Blanca is a census-designated place in Texas' eastern county of Hudspeth, just north of the Mexican-American border.

Her fans quickly took to Twitter with the hashtag "freefiona". No guessing how they'll react to this confusing apology of sorts.

[Photo Credit: RD/Kabik/Retna Digital]

Follow Anna on Twitter @thebrandedgirl

More:
Fiona Apple Arrested at Border Stop for Hashish
Britney, Jessica, Christina, Adele, Lady Gaga: Stop Body-Shaming Pop Stars
Fiona Apple's Bizarrely Named Album Gets Equally Wacky Cover Art

Source: http://feeds.hollywood.com/~r/hollywoodcom_recent_news/~3/KnmLmRBjRVs/40680496

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Make More Money Than You Know What To Do With Using These ...

Creating your own business, becoming your own boss and working your preferred schedule are all amazing things. Becoming a successful Internet marketer can make those dreams possible, and the tips provided here can help you get started.

Determine whether your marketing campaign is a success or a failure by checking how many sales you get per 1000 affiliate clicks. Most major companies online offer various add-ons and trackers, which allow you to see the comparison of visitors to sales numbers and repeat customers.

Use high-quality images that give visitors a good idea of what kind of products you are selling. Customers are more likely to buy from you if they can see a clear example of what they?re ordering. Allow customers to post their own images of your products to show how they use them. You can also use ?before and after? shots for more effect.

TIP! When you take time and learn the fundamentals of web designing you will succeed. Use the Internet to find information about CSS and HTML.

If you are already using internet marketing, you know which of your products are top sellers. Take advantage of these successful products to promote the rest of your products. Point customers towards accessories and other items that go with your best sellers. These complementary products are sold through your more popular products and may not require the same amount of advertising as completely unrelated products.

Review your business website from the perspective of a customer. Is it simple to use? Is the content enjoyable and interesting? Is it easy to place orders? You?re going to invest plenty of time and effort in drawing people to your site; it would be a shame if they turned away at the last minute because they find it confusing or boring.

Create a website adapted to your target audience. If you can give them what they are looking for, you will see your marketing efforts pay off in more sales for the product. Also, solicit objective opinions regarding your website. Ask friends or family, or even ask for comments from those in a marketing forum. It is very important that you do plenty of research and construct a site that will help people get what they want.

TIP! You can trick your readers into clicking on the ads you have by creating an image that is discreet and that will link your readers to a product page. Have it blend nicely with the text on your page by using the same font.

One Internet marketing tactic you may not have considered is to target image searches. If you put images that are relevant to your niche you can get more hits than if someone was searching for text only. Your site could inadvertently attract visitors who have stumbled across it while looking for others. Once they have been to your site and are familiar with your brand, they are more apt to visit again in the future.

Increasing the number of subscribers will increase your income. Split tests are a great way to find out how your website is doing. Split tests work by showing one group a version of a website, and then showing a second group a different version. Based upon the results of this test, you should be able to see which version received the most subscriptions.

TIP! It is a good idea to keep contact information for your customers. Allow sign-ups on your site or require emails for purchases.

Try to place banners on your web site that do not have the appearance of being banners. Instead, try to make them appear to be a clickable link to more content. Internet savvy visitors are not inclined to give banners a click, but they may try one that promises to give them something of value.

Add a banner to the top of your website that describes your companies mission. This will help visitors understand what your company is all about. This will help you highlight your services and the reasons for your commitment to your products and customers.

Have you considered making a video to showcase some of your products? Don?t forget to put a link leading to your site in the video?s description. That is going to dramatically affect your site visits.

TIP! Try getting legitimate people in your industry to do interviews. Always get permission before publishing to your site so you won?t have legal blowback.

One way to improve the success of your internet marketing efforts is with a blog that you update on a regular basis. Consistent blogging provides yet another way to keep your customers informed. By adding a blog to your website you are also increasing its size, which has the side effect of increasing your search engine ranking.

Making sure to include captions in your images is a great tip to employ. Captions play a big role with regards to SEO. If you include quality descriptions of everything on your site you will ensure that your rank will raise in ranks.

Making and maintaining a CRM or customer relationship management database can help with Internet marketing. It can help you see past successes and guide you in the ways that your business and marketing strategies should be going. Another benefit is that you will see what extras your current customers might need, which you can then market directly to them.

TIP! When you are building your website, your goal should be to provide high quality, comprehensive content. Your goal should be to teach your potential customers exactly what you are selling so they understand what and why they should want to purchase your product.

Though Internet marketing is a road to success, supplement it with a direct marketing strategy as well. Contact your customers via email, phone or fax to let them know about any upcoming specials you may have. You can acquire much of the information you need by looking in the physical yellow pages or available online phone books.

Your business very well be small, but using internet marketing you can gain momentum. Don?t stop when you initials goals are satisfied, come up with new goals and continue to grow and improve. Research what you need to keep your approaches fresh and engaging. Implement the newest tools to keep your business successful and relevant

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www.facebook.com/maynaseric

Source: http://www.maynaseric.com/make-more-money-than-you-know-what-to-do-with-using-these-cutting-edge-internet-marketing-tips-2

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Pakistanis get the day off to protest insulting Mohammad movie

ISLAMABAD (Reuters) - Demonstrators clashed with police in the Pakistani city of Peshawar on Friday as anger over insults to the Prophet Mohammad boiled over despite calls from political and religious leaders across the Muslim world for peaceful protest.

Western diplomatic missions throughout the Muslim world tightened security, with some closing down on expectation of big protests after Friday prayers.

An anti-Islam film made in America has enraged Muslims and led to days of protests across the Muslim world while cartoons mocking the Prophet Mohammad published in a French magazine on Wednesday were expected to compound the anger.

Egypt's highest Islamic legal official said on Thursday Muslims should follow his example of enduring insults without retaliating.

But the call looked unlikely to calm the outrage.

"An attack upon the Holy Prophet is an attack on the whole 1.5 billion Muslims. Therefore, this is something unacceptable," Pakistani Prime Minister Raja Pervez Ashraf said in a speech to politicians, religious leaders and others.

[Related: 2,000 Muslims protest in Sri Lanka, demand U.S. punish filmmaker]

Pakistan has declared Friday a "Day of Love for the Prophet Mohammad". Critics of the unpopular government said it was pandering to Islamist parties.

Protesters took to the streets of the Pakistani city of Peshawar, an old frontier town on the main road to Afghanistan, and torched two cinemas and clashed with riot police who tried to disperse them with teargas.

At least five protesters were hurt, a doctor at the city's main hospital said. The ARY television station said an employee had been killed.

[Related: Car bomb kills 5 in Thailand after warning]

Near the capital, Islamabad, protesters set fire to a motorway toll booth. The previous day, about 1,000 stone-throwing protesters clashed with police as they tried to force their way to the U.S. embassy.

The government shut down mobile phone services in more than a dozen cities as part of security arrangements ahead of protests expected on Friday.

The U.S. embassy in Pakistan has been running television advertisements, one featuring Secretary of State Hillary Clinton, saying the government had nothing to do with the film.

"TALIBAN INFLUENCE"

The U.S. and French embassies were closed on Friday in Jakarta, capital of Indonesia, which has the world's biggest Muslim population, and diplomatic missions in the Afghan capital, Kabul, were on lock-down.

Police in Kabul said they had been in contact with religious and community leaders to try to prevent violence.

"There are some angry demonstrators who will encourage people to violence," senior police officer Mohammad Zahir told Reuters. "There will also be Taliban influence in demonstrations too and they may attack the U.S. and other embassies."

About 10,000 Islamists gathered in the Bangladeshi capital, Dhaka, after Friday prayers to chant anti-U.S. and anti-French slogans. They burned those countries' flags and an effigy of U.S. President Barack Obama.

[Related: France bans protests over Prophet Mohammad cartoons]

The cartoons in France's Charlie Hebdo satirical weekly have provoked relatively little street anger, although about 100 Iranians demonstrated outside the French embassy in Tehran.

Western embassies tightened security in Sanaa, fearing the cartoons could lead to more unrest in the Yemeni capital where crowds attacked the U.S. mission last week over an anti-Islam film made in America.

In Tunisia, the birthplace of the Arab Spring revolts, the Islamist-led government decreed a ban on protests planned on Friday against the cartoons. Four people died and almost 30 were wounded last week when protesters incensed by the movie about the Prophet Mohammad stormed the U.S. embassy.

Condemning the publication of the cartoons in France as an act verging on incitement, Egypt's Grand Mufti Ali Gomaa said on Thursday it showed how polarised the West and the Muslim world had become.

Gomaa said Mohammad and his companions had endured "the worst insults from the non-believers of his time. Not only was his message routinely rejected, but he was often chased out of town, cursed and physically assaulted on numerous occasions.

"But his example was always to endure all personal insults and attacks without retaliation of any sort. There is no doubt that, since the Prophet is our greatest example in this life, this should also be the reaction of all Muslims."

In Libya, where militias that helped overthrow Muammar Gaddafi still wield much power, the foreign minister offered a further apology for U.S. ambassador Christopher Stevens' death to visiting U.S. Deputy Secretary of State William Burns on Thursday.

Stevens and three other Americans died in an attack on the U.S. consulate in the eastern city of Benghazi by gunmen among a crowd protesting against the film that denigrated the Prophet.

(Writing by Alistair Lyon and Robert Birsel; Additional reporting by Katharine Houreld in Islamabad, Mirwais Harooni in Kabul, Serajul Qadir in Dhaka and bureaus in the Middle East and Europe; Editing by Jonathan Thatcher)

Source: http://news.yahoo.com/egypts-mufti-urges-muslims-endure-insults-peacefully-054427311.html

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Islamist militia withdraws from Benghazi base: witnesses

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