Improving medical treatment requires risk-based approach to regulate clinical trials

Public release date: 30-Jan-2012
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Contact: Elizabeth de Bony
elizabeth.debony@bm.com
32-274-36652
European Science Foundation

Strasbourg/Brussels -- Current EU legislation represents a major hurdle to improving medical treatment due to the straight-jacket of EU legislation that the 2001 Clinical Trials Directive imposes, a group of leading European medical scientists charged today in a position paper1 issued in Brussels and Strasbourg.

The paper issued by the European Science Foundation (ESF) and its European Medical Research Councils (EMRC) welcomes the planned revision of the 2001 Clinical Trials Directive expected later this year, but urges the Commission to take the opportunity to introduce a series of improvements to the Directive. These improvements include streamlining procedures, introducing a risk-based approach to authorising clinical trials and crucially ensuring greater harmonisation in the implementation of EU rules at national level so that clinical trials can take place across national borders.

"Balancing these aims with the imperative of maintaining a high level of patient safety is the major challenge facing the revision," said Professor Liselotte Hjgaard, Chair of the EMRC.

Finding that balance, however, is the key to preserving Europe's position as an innovative and competitive research area.

The 2001 Directive was a landmark in the pursuit of quality medicine in Europe. It aimed to facilitate clinical research across the EU, while at the same time maintaining a high level of protection for public health. It established specific provisions regarding the conduct of clinical trials on humans involving medicinal products in particular relating to the implementation of good clinical practice defined as a set of internationally recognised ethical and scientific quality requirements which must be observed for designing, conducting, recording and reporting clinical trials.

1 The position paper "Proposal for a revision of the 'Clinical Trials Directive (2001/20/EC) and other recommendations to facilitate clinical trials" is available on the ESF website: www.ESF.org

It is widely recognised that the 2001 Directive radically enhanced the quality of Europe's clinical trials on which patient safety resides, and the ESF, EMRC and many other European organisations want the revision to preserve that high standard. But in line with Europe's 2020 objectives it must also be designed to boost innovation and improve medical treatments.

Since its implementation in 2003 the Directive has been under a lot of criticism for adding to rather than reducing red tape. No one argues the benefits of the strict regulations for high risk trials involving experimental medicines for humans, but the EMRC argues in favour of a sliding scale of requirements depending precisely on the risk involved. In this way low-risk trials or comparative trials could benefit from a less restrictive framework than high risk trials. Clinical researchers wanting to verify the effectiveness of one already licensed medication over another aspirin versus paracetamol for example would not have to fulfil the full gamut of rules. "It is time now to align requirements with the risk involved," stressed Prof Hjgaard.

Another key objective for research is to harmonise national implementation of the clinical trials directive. Currently the 27 member states have each translated the Directive into national law with different definitions and varying restrictions so every pan-European trial has to deal with that complexity. This is a non-starter for academic research groups with a low research budget. The EMRC therefore welcomes indications from the Commission that improved harmonisation and cooperation in clinical trials will be part of the revised legislative.

"Excellence in clinical research requires a truly functioning harmonisation," emphasised Professor Hjgaard. "We urge the Commission, European Parliament and the member states to enact a law that unifies clinical trials in Europe."

###

For further information please contact:

At the European Science Foundation

Prof Liselotte Hjgaard, EMRC Chair
University of Copenhagen and Danish Technical University, Denmark
45-3545-4215 or 45-3545-1792 / lottepet@rh.dk

Dr. Kirsten Steinhausen, Science Officer
Biomedical Sciences Unit
33-3-88-76-2184 / KSteinhausen@esf.org

Shira Tabachnikoff, Head of Communications
33-3-88-76-71-32 / stabachnikoff@esf.org

At Burson-Marsteller in Brussels

Elizabeth de Bony, Director
32-2-743-66-52 /elizabeth.debony@bm.com

Notes to editors

The European Science Foundation (ESF) The European Science Foundation (ESF) was established in 1974 to provide a common platform for its Member Organisations to advance European research collaboration and explore new directions for research. It is an independent organisation, owned by 78 Member Organisations which are research funding organisations and research performing organisations, academies and learned societies from 30 countries. ESF promotes collaboration in research itself, in funding of research and in science policy activities at the European level. www.esf.org

The European Medical Research Councils (EMRC) is the membership organisation for all the Medical Research Councils in Europe under the ESF. The EMRC's is to promote innovative medical research and its clinical application towards improved human health. EMRC offers authoritative strategic advice for policy making, research management, ethics, and better health services. In its activities, EMRC serves as a voice of its Member Organisations and the European scientific community. EMRC disseminates knowledge and promotes the socio-economic value of medical research to the general public and the decision makers.

---

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?

AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.

Public release date: 30-Jan-2012
[ | E-mail | Share ]

Contact: Elizabeth de Bony
elizabeth.debony@bm.com
32-274-36652
European Science Foundation

Strasbourg/Brussels -- Current EU legislation represents a major hurdle to improving medical treatment due to the straight-jacket of EU legislation that the 2001 Clinical Trials Directive imposes, a group of leading European medical scientists charged today in a position paper1 issued in Brussels and Strasbourg.

The paper issued by the European Science Foundation (ESF) and its European Medical Research Councils (EMRC) welcomes the planned revision of the 2001 Clinical Trials Directive expected later this year, but urges the Commission to take the opportunity to introduce a series of improvements to the Directive. These improvements include streamlining procedures, introducing a risk-based approach to authorising clinical trials and crucially ensuring greater harmonisation in the implementation of EU rules at national level so that clinical trials can take place across national borders.

"Balancing these aims with the imperative of maintaining a high level of patient safety is the major challenge facing the revision," said Professor Liselotte Hjgaard, Chair of the EMRC.

Finding that balance, however, is the key to preserving Europe's position as an innovative and competitive research area.

The 2001 Directive was a landmark in the pursuit of quality medicine in Europe. It aimed to facilitate clinical research across the EU, while at the same time maintaining a high level of protection for public health. It established specific provisions regarding the conduct of clinical trials on humans involving medicinal products in particular relating to the implementation of good clinical practice defined as a set of internationally recognised ethical and scientific quality requirements which must be observed for designing, conducting, recording and reporting clinical trials.

1 The position paper "Proposal for a revision of the 'Clinical Trials Directive (2001/20/EC) and other recommendations to facilitate clinical trials" is available on the ESF website: www.ESF.org

It is widely recognised that the 2001 Directive radically enhanced the quality of Europe's clinical trials on which patient safety resides, and the ESF, EMRC and many other European organisations want the revision to preserve that high standard. But in line with Europe's 2020 objectives it must also be designed to boost innovation and improve medical treatments.

Since its implementation in 2003 the Directive has been under a lot of criticism for adding to rather than reducing red tape. No one argues the benefits of the strict regulations for high risk trials involving experimental medicines for humans, but the EMRC argues in favour of a sliding scale of requirements depending precisely on the risk involved. In this way low-risk trials or comparative trials could benefit from a less restrictive framework than high risk trials. Clinical researchers wanting to verify the effectiveness of one already licensed medication over another aspirin versus paracetamol for example would not have to fulfil the full gamut of rules. "It is time now to align requirements with the risk involved," stressed Prof Hjgaard.

Another key objective for research is to harmonise national implementation of the clinical trials directive. Currently the 27 member states have each translated the Directive into national law with different definitions and varying restrictions so every pan-European trial has to deal with that complexity. This is a non-starter for academic research groups with a low research budget. The EMRC therefore welcomes indications from the Commission that improved harmonisation and cooperation in clinical trials will be part of the revised legislative.

"Excellence in clinical research requires a truly functioning harmonisation," emphasised Professor Hjgaard. "We urge the Commission, European Parliament and the member states to enact a law that unifies clinical trials in Europe."

###

For further information please contact:

At the European Science Foundation

Prof Liselotte Hjgaard, EMRC Chair
University of Copenhagen and Danish Technical University, Denmark
45-3545-4215 or 45-3545-1792 / lottepet@rh.dk

Dr. Kirsten Steinhausen, Science Officer
Biomedical Sciences Unit
33-3-88-76-2184 / KSteinhausen@esf.org

Shira Tabachnikoff, Head of Communications
33-3-88-76-71-32 / stabachnikoff@esf.org

At Burson-Marsteller in Brussels

Elizabeth de Bony, Director
32-2-743-66-52 /elizabeth.debony@bm.com

Notes to editors

The European Science Foundation (ESF) The European Science Foundation (ESF) was established in 1974 to provide a common platform for its Member Organisations to advance European research collaboration and explore new directions for research. It is an independent organisation, owned by 78 Member Organisations which are research funding organisations and research performing organisations, academies and learned societies from 30 countries. ESF promotes collaboration in research itself, in funding of research and in science policy activities at the European level. www.esf.org

The European Medical Research Councils (EMRC) is the membership organisation for all the Medical Research Councils in Europe under the ESF. The EMRC's is to promote innovative medical research and its clinical application towards improved human health. EMRC offers authoritative strategic advice for policy making, research management, ethics, and better health services. In its activities, EMRC serves as a voice of its Member Organisations and the European scientific community. EMRC disseminates knowledge and promotes the socio-economic value of medical research to the general public and the decision makers.

---

[ | E-mail | Share ]

?

AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.

Source: http://www.eurekalert.org/pub_releases/2012-01/esf-imt013012.php

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Video: Obama will rally the nation

Broken heart may become a diagnosis

??NYT: In a bitter skirmish over the definition of depression, a new report contends that a proposed change to the diagnosis would characterize grieving as a disorder and greatly increase the number of people treated for it.

Source: http://www.msnbc.msn.com/id/3036697/vp/46122446#46122446

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Villarreal beats Sporting 3-0 to end 10-game slump

updated 7:56 p.m. ET Jan. 23, 2012

VILLARREAL, Spain - Villarreal ended a 10-game winless streak, scoring three second-half goals to beat Sporting Gijon 3-0 in the Spanish league on Monday night.

Striker Marco Ruben returned from an injury to score in the 57th minute, Borja Valero doubled the lead with a powerful shot beat goalkeeper Juan Pablo a minute later and Bruno Soriano added the final goal in stoppage time.

Villarreal hadn't won since beating Real Betis on Nov. 19. At the halfway point, Villarreal (4-8-7) and Granada (5-10-4) have one point more than 19th-place Sporting (5-11-3).

Copyright 2012 The Associated Press. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.

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More newsGiuseppe Cacace / AFP - Getty Images

Barca awaits Real Madrid again

Real Madrid probably will abandon its defensive strategy and go on the attack against Barcelona in the second leg of the Copa del Rey quarterfinals on Wednesday.

Stefano Rellandini / Reuters

That's a reason?

AC Milan's Kevin-Prince Boateng is hurt again, and his girlfriend says it's because they have sex "7-10 times a week." Oh.

Source: http://nbcsports.msnbc.com/id/46108421/ns/sports-soccer/

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Santorum To Rape Victims: 'Accept What God Has Given You' (Little green footballs)

Share With Friends: | | Politics - Top Stories Stories, News Feeds and News via Feedzilla.

Source: http://news.feedzilla.com/en_us/stories/politics/top-stories/190578193?client_source=feed&format=rss

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France votes on genocide law, faces Turkish reprisals (Reuters)

PARIS (Reuters) ? French senators vote later on Monday on a bill to make it illegal to deny the mass killing of Armenians by Ottoman Turks nearly a century ago was genocide, raising the prospect of a major diplomatic rift between two NATO allies.

Lawmakers in the lower-house National Assembly voted overwhelmingly in December for the draft law outlawing genocide denial, prompting Ankara to cancel all economic, political and military meetings with Paris and recall its ambassador for consultations.

The bill, which has been made more general so that it outlaws the denial of any genocide, partly in the hope of appeasing the Turks, will be debated from 3 p.m. (10 a.m. ET) in the upper house before a final vote.

Armenia, backed by many historians and parliaments, says about 1.5 million Christian Armenians were killed in what is now eastern Turkey during World War One in a deliberate policy of genocide ordered by the Ottoman government.

The Ottoman empire was dissolved soon after the end of World War One, but successive Turkish governments and the vast majority of Turks feel the charge of genocide is a direct insult to their nation. Ankara argues that there was heavy loss of life on both sides during fighting in the area.

Turkish Foreign Minister Ahmet Davutoglu said Ankara would take new and permanent measures against France unless the bill was rejected.

"After this the values of Europe will face a big threat. If every parliament implements decisions reflecting its own historical views a new Inquisition period will begin in Europe," Davutoglu was reported as saying by Dogan news agency. "We all know what happened during the Inquisition in the Middle Ages. Unfortunately the revival of this is shameful for France."

Turks from across Europe demonstrated in central Paris at the weekend, with more protests due on Monday before the vote. Turkish lobby groups carried full page advertisements in French newspapers urging senators to back down.

The Socialist Party, which has had a majority in the Senate since elections in the upper house late last year, and the Senate leader of President Nicolas Sarkozy's UMP party, which put forward the bill, have said they will back the legislation.

But a non-binding Senate recommendation last week said the law would be unconstitutional, and after weeks of aggressive Turkish lobbying there are suggestions the outcome will be closer than anticipated.

Turkey calls the bill a bid by President Nicolas Sarkozy to win the votes of 500,000 ethnic Armenians in France in the two-round presidential vote on April 22 and May 6.

Sarkozy wrote to Turkish Prime Minister Tayyip Erdogan last week saying the bill did not single out any country and that Paris was aware of the "suffering endured by the Turkish people" during the final years of the Ottoman empire.

European Union candidate Turkey could not impose economic sanctions on France, given its World Trade Organisation membership and customs union accord with Europe.

But the row could cost France state-to-state contracts and would create diplomatic tension as Turkey takes an increasingly influential role in the Middle East.

The bill mandates a maximum 45,000-euro fine and a year in jail for offenders. France passed a law recognizing the killing of Armenians as genocide in 2001.

(Reporting By John Irish and Daren Butler in Istanbul)

Source: http://us.rd.yahoo.com/dailynews/rss/asia/*http%3A//news.yahoo.com/s/nm/20120123/wl_nm/us_france_turkey_genocide

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AP Exclusive: US talks to Afghan insurgent group (AP)

ISLAMABAD ? Anxious to accelerate peace moves, top-level U.S. officials have held talks with a representative of an insurgent movement led by a former Afghan prime minister who has been branded a terrorist by Washington, a relative of the rebel leader says.

Dr. Ghairat Baheer, a representative and son-in-law of longtime Afghan warlord Gulbuddin Hekmatyar (Gul-bu-DEEN HEK-mah-tyar), told The Associated Press this week that he had met separately with David Petraeus, former commander of NATO forces in Afghanistan and now CIA director, and had face-to-face discussions earlier this month with U.S. Ambassador Ryan Crocker and U.S. Marine Gen. John Allen, currently the top commander in the country.

Baheer, who was released in 2008 after six years in U.S. detention at Bagram Air Field in Afghanistan, described his talks with U.S. officials as nascent and exploratory. Yet, Baheer says the discussions show that the U.S. knows that in addition to getting the blessing of Taliban chief Mullah Mohammad Omar ? a bitter rival of Hekmatyar even though both are fighting international troops ? any peace deal would have to be supported by Hekmatyar, who has thousands of fighters and followers primarily in the north and east.

Hizb-i-Islami, which means Islamic party, has had ties to al-Qaida but in 2010 floated a 15-point peace plan during informal meetings with the Afghan government in Kabul. At the time, however, U.S. officials refused to see the party's delegation.

"Hizb-i-Islami is a reality that no one can ignore," Baheer said during an interview last week at his spacious home in a posh suburb of Pakistan's capital, Islamabad. "For a while, the United States and the Kabul government tried not to give so much importance to Hizb-i-Islami, but now they have come to the conclusion that they cannot make it without Hizb-i-Islami."

In Washington, National Security Council spokeswoman Caitlin Hayden would not confirm that such meetings took place but said the U.S. was maintaining "a range of contacts in support of an Afghan-led reconciliation process."

On Saturday, Afghan President Hamid Karzai said he also had met recently with Hizb-i-Islami representatives. Baheer said he attended those meetings but added that the party considers the Afghan government corrupt and lacking legitimacy.

Karzai's announcement appeared intended to bolster his position as the key player in the search for peace. The U.S. repeatedly has said that formal negotiations must be Afghan-led, but Karzai has complained that his government has not been directly involved in recent preliminary talks with Taliban representatives and plans for setting up a Taliban political office in the Gulf state of Qatar.

Baheer said his meeting with Petraeus, whom he described as a "very humble, polite person," was marked by a few rounds of verbal sparring with each boasting a battlefield strength that the other dismissed as exaggerated.

"There was a psychological war in these first meetings," he said.

Baheer said Crocker and Allen tried to persuade Hizb-i-Islami to become part of Afghanistan's political network, accept the Afghan security forces and embrace the nation's current constitution. He said Hizb-i-Islami was ready to accept the security forces and the constitution, but wants a multiparty commission established to review and revise the charter.

"We are willing to make compromises," said Baheer. "We already have said we will accept the Afghan army and the police."

He said Hizb-i-Islami envisioned a multiparty government in postwar Afghanistan. At the same time, the group wants all U.S. and NATO forces, including military trainers, to leave Afghanistan, he said.

"The presence of any foreign forces will be not acceptable to us under any cover," he said. "Daily, there is another American killing of civilians. The longer they stay, the more they are hated by the Afghan people."

Overtures to Hekmatyar's group show not only the degree of U.S. interest in pursuing a settlement but also the complexity of putting together an agreement acceptable to all sides in factious Afghanistan. The U.S. formally declared Hekmatyar a "global terrorist" in 2003 because of alleged links to al-Qaida and froze all assets which he may have in the United States.

Hekmatyar, who is in his mid-60s, was among the major recipients of U.S. aid during the Afghan war against the Soviets in the 1980s. He and other anti-Soviet commanders swept into Kabul in 1992 and ousted the pro-Soviet government, only to turn against one another in a bitter and bloody power struggle that destroyed vast sections of the Afghan capital and killed an estimated 50,000 civilians before the Taliban seized the city.

A bitter rival of Mullah Omar, Hekmatyar fled to Iran and remained there until the Taliban were ousted in the 2001 U.S.-led invasion. He declared war on foreign troops in his country and rebuilt his military forces, which by 2008 had become a major threat to the U.S.-led coalition.

Contacts with Hekmatyar's group as well as parallel efforts to negotiate with the Taliban have taken on new urgency following the NATO decision to withdraw foreign combat forces, transfer security responsibility to the Afghans by the end of 2014 and bring an end to the unpopular war, which is increasingly seen as a drain on the financially strapped Western countries that provide most of the troops.

On Sunday, the U.S. special envoy to Afghanistan and Pakistan, Marc Grossman, completed two days of meetings about the peace process with Karzai and other Afghan officials. Grossman, who was to travel to Qatar on Monday, urged the Taliban to issue a "clear statement" against international terrorism and affirm their commitment to the peace process "to end the armed conflict in Afghanistan."

U.S. officials also have reached out to the Pakistan-based Haqqani militant network to test its interest in peace talks. Haqqani fighters, the second largest insurgent group after the Taliban, have been blamed for most of the high-profile attacks in the heart of the Afghan capital.

___

Kathy Gannon is AP special regional correspondent covering Pakistan and Afghanistan. She can be reached at http://www.twitter.com/kathygannon

___

Associated Press writers Deb Riechmann in Kabul and Kimberly Dozier and Anne Gearan in Washington contributed to this report.

Source: http://us.rd.yahoo.com/dailynews/rss/terrorism/*http%3A//news.yahoo.com/s/ap/20120122/ap_on_re_as/as_afghan_talks

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97% The Artist

The Artist I don't know how to say it, pun intended, but The Artist is by far one of the best movies ever. With no words to describe how amazing this movie is, I will try my best to scribble all the great things that make this, one of the best movies out there. George Valentin (Dujardin) is a silent movie star. However, with the arrival of talking pictures, this famous movie star's life is bound to be changed. The movie essentially touches upon the dichotomy of the old and the new, the clash between traditional vs. advanced, and on top of that a beautiful romance. Honestly, it is merely impossible to describe how good this movie is. It's uniqueness and experimental ideas are breathtaking. Michel Hazanavicius is Godly in this film. He treats every scene with so much care, and every shot in his film is perfect and cannot be changed. Not only due to his originality, but also to his artistic sense, Hazanavicius is able to magically create a movie, that unlike a 3D film, has all dimensions. In his simple, yet complex film, he is able to take a plain and easy story, and turn it into a vivid and intricate movie. He is able to touch upon many themes but in his subtle way. However, what is best about him is that he takes risk; he uses techniques no other director has used before and I very much appreciate that. The story of the film is somehow simple, however it is like a roller coaster with ups and downs that will make you laugh and frown. The movie is able to touch the audience in every way, and with its simplistic lack of words we are able to enjoy the movie in a way we haven't enjoyed movies in a long time. Jean Dujardin, is brilliant; I have never seen him act before, but just from this movie I can honestly say that he deserves every award out there. The role he takes is by far one of the hardest role to take nowadays, and he does it wonderfully. As for the other actors in this movie like Bejo and Goodman they also have their moments.The sound of this movie is fundamental, hence the score has to be perfect, and it is. Every scene has a song that is able to run down your skin and your bones, and touch your heart. The music controls your heart, it can make it go faster and it can make it go slower. The photography of this movie is also mind blowing. In only black and white, this movie develops some of the most beautiful photography ever developed in movie history. The cameras are playful and every image projected gave me goosebumps. Therefore ladies and gentelmen, don't miss out on this movie. This is by far the best film of 2011, with some exceptions, and one of my favorite films of all time. It's uniqueness, simplicity, and beauty makes this movie unforgetable. George Valentin : "With pleasure"

November 1, 2011

Source: http://www.rottentomatoes.com/m/the_artist/

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ZTE pays Microsoft around $27 for each Windows Phone made

How much does it cost to license Microsoft's latest and greatest mobile OS? A fair bit it seems. While numbers have been bandied around before, this is the first time a per-handset figure was to an internal employee -- this time, the portfolio manager for ZTE UK, no less. Pegged at $27 per ZTE smartphone, TrustedReviews managed to get those licensing beans spilled at the glitzy London launch of the company's first Windows Phone, the ZTE Tania. The fee flies in the face of open-source Android, which requires no price to install on handsets. Microsoft, however, is still keeping an eye on its Google rival, collecting patent licensing fees from several major phone manufacturers. ZTE hasn't yet commented on the figure.

ZTE pays Microsoft around $27 for each Windows Phone made originally appeared on Engadget on Thu, 19 Jan 2012 19:23:00 EDT. Please see our terms for use of feeds.

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Daughter says life of Ukraine's Tymoshenko "at risk" (Reuters)

KIEV (Reuters) ? The daughter of jailed Ukrainian opposition leader Yulia Tymoshenko says her mother's life is now at risk after President Viktor Yanukovich "crossed a fine line" when he rejected all early chances of compromise to free her.

In an interview, Yevgenia Tymoshenko urged the West to consider applying personal sanctions against officials of the Yanukovich leadership, such as visa bans, to stop it driving Ukraine further into isolation in Europe.

Tymoshenko, Yanukovich's arch-rival who was twice prime minister, is serving a seven-year jail sentence for abuse of office following a trial widely seen as a settling of scores between rival groups of influence in the ex-Soviet republic.

The United States and the European Union say the trial was politically motivated; in December the EU withheld completion of agreements on political association and a free trade zone with Ukraine in protest over her jailing.

But despite diplomatic pressure from EU countries for her release, fresh criminal cases have been opened against her by justice officials and she has been moved from police detention in Kiev to a remote prison camp some 500 km (310 miles) east.

"It (the situation) is unpredictable now ... They have crossed the line where my mother's life now is at risk," said Yevgenia, speaking in English in Kiev at the riverside headquarters of her mother's party, Batkivshchyna.

"This line is a kind of fine line and once the regime crossed it we do not know now what could be the consequence of this war ... against political opponents. The regime is doing all it can to break her morale, to break her psychologically."

Tymoshenko's husband, Olexander, took asylum in the Czech Republic earlier this month out of fear he also was about to be arrested, leaving the English-educated, 31-year-old Yevgenia the only close relative left in Kiev.

"CONSTANT PAIN"

Yevgenia, who is married to a British rock singer, now makes a six-hour car trip from Kiev to the prison in Kharkiv twice a week to see her mother, whose health and conditions are the subject of an information battle between her lawyers and officials.

Yevgenia says her mother is in constant pain from a recurring back problem and has not been able to get up unaided since early November.

"The health ministry denies this. They say she does not require medical treatment, that she needs exercise. When I see her, I have to pick her up. I have to move her, to help her stand up and it is evident that any slight movement causes very sharp pain," she said. "She is much paler and weaker."

The family has also complained that she is under constant surveillance from a video camera with a light on in her cell round the clock.

"The video camera is a microscopic one that can see what she is writing in bed. Whatever she writes they can see and this causes a lot of psychological, moral strain ...," said Yevgenia.

The charismatic 51-year-old Yulia Tymoshenko, a political power-house, was the field marshal of the Orange Revolution street protests which thwarted Yanukovich's first bid for the presidency in 2005.

Though self-confident and equally stylish, Yevgenia is far less forceful than her mother and denies media reports that she has ambitions to step into her mother's shoes.

"I am far from being a public person. I see my mother continuing her political career ... She is the one in our family who is going to continue this," she said.

All the same, she does not shy from criticizing the Yanukovich leadership's record, repeating the mantra of her mother that its policies are alienating Ukraine within Europe.

"It seems like there are deliberate attempts by the Yanukovich regime to isolate Ukraine from the European Union," she said. "Only some direct action now can signal to the Yanukovich regime that they are going in the wrong direction."

She urged the West to restrict access to visas and foreign bank accounts for senior Ukrainian officials and investigate high-level corruption. "The only way to change the way the regime is acting now is by direct sanctions ... some sort of personal pressure," she said.

Tymoshenko was convicted of exceeding her powers as prime minister by railroading through a gas deal with Russia in 2009 which the Yanukovich leadership says saddled Ukraine with a huge price for gas that has become a millstone for the economy.

Political insiders say her prosecution was driven by Yanukovich who has been Tymoshenko's political enemy since the Orange Revolution overturned his election as president.

He later made a comeback and narrowly beat Tymoshenko for the presidency in 2010 after a bitter campaign.

(Writing By Richard Balmforth; editing by Philippa Fletcher)

Source: http://us.rd.yahoo.com/dailynews/rss/europe/*http%3A//news.yahoo.com/s/nm/20120120/wl_nm/us_ukraine_tymoshenko_daughter

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Automotive Parts | Auto Information

Automotive Parts

Automotive parts are the different components (or spare parts) of an automobile. Every automobile owner will have to shop for automotive parts sooner or later. Contrary to popular belief, automotive parts are not manufactured only by the original manufacturing company (of your automobile) but also by various independent (engineering) companies that specialize in manufacturing and installing automotive parts of a diverse range of automobiles of different makes and models. Automotive parts (manufactured by the original manufacturing company of your automobile) are expensive in most cases. When you factor in the repair or installation charges you will have to pay at the workshop and cost of alternative transport, you would realize that it will make more financial sense to buy your automobile and purchase a new one.

Most car enthusiasts can and do have a certain degree of technical know-how and generic tools that are useful for basic repair work.

If you have undertaken thorough research and explored all the options before purchasing the automotive parts, you would probably have purchased them at a reasonable price. A large number of car enthusiasts save hundreds of dollars just because they have technical know-how and generic tools that allow them to do basic repair work and installation of their vehicles at home. Availability of automotive parts was a huge constraint some time back. Automobile owners could buy second hand parts from their repair workshop or order them from the original manufacturing company of their automobile.

Experts recommend investing in original equipment manufacturer automotive parts despite the fact that they are more expensive because they are superior in quality, more reliable and are made for the specific make and model of your automobile.

On the other hand, aftermarket parts are manufactured for your car by companies other than the original manufacturer and are designed (generically) for several (makes and models of) cars. The performance of aftermarket parts is unreliable at best. Moreover, because they are manufactured by relatively smaller (and unknown companies) there are no guarantees for aftermarket parts available in the market. Thus, do not be lured by the substantially lower price of aftermarket parts because chances are that they would make you spend more in the long run than original equipment manufacturer parts! It should also be kept in mind that original equipment manufacturer parts are not necessarily manufactured by your automobile?s manufacturing company but one or more other companies that have been authorized to manufacture these parts by your automobile?s manufacturing company.

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This entry was posted on Friday, January 20th, 2012 at 6:47 am and is filed under Articles. You can follow any responses to this entry through the RSS 2.0 feed. Both comments and pings are currently closed.

Source: http://www.bilfingerberger-bot.com/260/automotive-parts

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Much of Asia expects birth jump in Year of Dragon (AP)

TAIPEI, Taiwan ? Taiwan has one of the lowest birth rates in the world, but you wouldn't know that from visiting the obstetrics department at Taiwan Adventist Hospital. The hallways were abuzz this week with dozens of women lined up for ultrasound checks and other appointments with obstetricians.

It's not just a baby boom. It's a dragon baby boom.

The Year of the Dragon begins Monday, and the Chinese believe that babies born in this iteration of the 12-year Zodiac cycle are gifted with prodigious quantities of luck and strength. In ancient times the dragon was a symbol reserved for the Chinese emperor, and it is considered to be an extremely auspicious sign.

"We haven't had a scene like this in years," said hospital official Hung Tzu-chu.

A second child had not been in the plans for Austin Tseng, a 32-year-old office worker, but she said at the hospital in downtown Tapei that she is eagerly awaiting the birth.

"I had thought one child was enough, but then comes the Year of the Dragon and I'm happy to have another one," Tseng said after an ultrasound check on her 20-week-old fetus.

Officials expect a baby boom not only in China and Taiwan, but in other Asian countries and territories that observe the New Year festival, including Japan, South Korea, Vietnam, Hong Kong and Macau.

Most have extremely low birth rates, reflecting a preference among young couples in these prosperous or rapidly developing societies to choose quality of life and career advancement over the responsibilities of child rearing.

But this Year of the Dragon looks to be breaking the mold. A poll in Hong Kong showed that 70 percent of couples there wanted children born under the dragon sign, while South Korea, Vietnam and China all report similar enthusiasm about dragon-year childbearing.

In Taiwan, Year of the Dragon childbearing fever is in full swing, with local banks selling silver and gold coins engraved with the dragon symbol. Bank officials believe that many are buying them for their own yet-to-be born dragon year babies or for those of expecting friends and relatives.

In the past, "many women wanted to keep their quality of life and thought child-rearing was too much of a burden to bear," said Wu Mei-ying, an interior ministry official charged with child care. "But with people all around them talking about bearing dragon sons and daughters, they are suddenly caught up in the baby craze."

The Year of the Dragon comes as a godsend for Taiwanese officials, who for the past decade have been trying to increase the island's low fertility rate: less than one child for every Taiwanese woman of childbearing age in 2010. In the 1950s, when Taiwan was a primarily agricultural society, women gave birth to an average of seven children.

The Year of the Dragon has long proved to be an impetus for births. In 2000, the last dragon year, the rate increased to 1.7 children per Taiwanese woman of childbearing age from 1.5 the previous year.

Taiwan has tried to encourage families with cash incentives that while well intentioned, appear to do little to dent the cost of education and other child rearing outlays. Besides a $100 monthly child care stipend, a Taiwanese woman can receive $330 from the government for delivering her first baby, double that for the second and triple for the third.

Interior Minister Chiang Yi-hua thinks that government encouragement can help boost the birthrate to 1.2 babies per fertile woman not only in the Year of the Dragon, but well beyond.

Wu, the interior ministry official, shares that view, noting that last year, the number of Taiwanese marriages shot up 19 percent, apparently paced by the belief that the 100th anniversary of the Republic of China ? Taiwan's official name ? was a favorable omen for long lasting and happy marriages.

"Coming on the heel of the centenary, the Year of the Dragon may encourage newlyweds to have babies soon," she said.

Chu Hong-min, a 30-year-old accountant, is five months pregnant and eagerly awaiting a dragon daughter to keep her 2-year-old son company.

But she also worries the incipient baby boom means her yet-to-be-born daughter will face tougher competition than usual.

"Many of my friends and colleagues are either expecting or plan to get pregnant this year," she said. "We really have to try harder to make the children do well at school."

Source: http://us.rd.yahoo.com/dailynews/rss/asia/*http%3A//news.yahoo.com/s/ap/20120120/ap_on_re_as/as_taiwan_dragon_babies

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Exclusive: Nick Cannon Talks 'Healthy Living'

'I don't get to eat the things that I like,' Cannon says in first on-camera interview since his hospitalization.
By Nadeska Alexis

Nick Cannon
Photo: MTV News

On Tuesday (January 17) Nick Cannon returned to the office for his first day back to work after being hospitalized for kidney failure two weeks ago. After an initial diagnosis of kidney stones, doctors determined that Cannon's kidneys were beginning to fail thanks to an overdose of protein, medication he was taking and a lack of proper sustenance. Sitting at his desk, Cannon told MTV News that his road to recovery includes a new diet, which forces him to cut back on some of his favorite eats.

"I'm feeling good, I'm in the office, I'm grinding, the only thing that sucks is that I'm on the renal diet," Cannon said. "It's all about healthy living and fueling your system, but I don't get to eat the things that I like to eat. You've got to stay hydrated and [eat] fruits and vegetables for breakfast."

After admitting that a more typical breakfast would usually include Lucky Charms cereal ("I can't have none of that stuff anymore"), Cannon explained that simple foods like oats are now on the menu.

"Not even the good oatmeal," Cannon said. "Real oats, like horse-feed stuff — but it's cool. I've got to start to love it."

According to Cannon, the diet will be implemented in phases, and as his body slowly recovers, he'll be able to incorporate Lucky Charms and other banned foods into his regimen once again.

"Right now I'm still on the strict diet and I can't have any sodium, but as a couple of weeks go by and everything gets leveled out, then I can start having low sodium," he said, revealing that hot sauce has been his solution for adding spice to his diet. "I can still have Tabasco sauce, so I'm excited about that because I love hot sauce. I'll be putting Tabasco sauce on carrots, like, 'This tastes delicious!' "

Dietary restrictions aside, the entertainment mogul and father of two is also reassessing his approach to healthy living. His hesitation to visit doctors, for example, is out the door. "I feel 100 percent right now, but obviously the doctors tell you to take it slow," he said. "This is definitely the first time anything like this has ever happened to me. I've always thought that I was doing the right things, but that's why I now encourage everybody to get checkups, get physicals, know what's going on in your system and don't play around with your body.

"I always considered myself as someone who was in great shape, but I was doing too much [to my body] so my immune system got confused and just started attacking my kidneys," he continued. "You look at my Twitter picture and I look like I'm in shape, but I was putting the wrong stuff into my body, speeding all the time, not sleeping and eating properly — it's all about taking time and really caring about yourself and how you fuel yourself."

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Source: http://www.mtv.com/news/articles/1677440/nick-cannon-post-hospital-diet.jhtml

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Well: Daily Aspirin Is Not for Everyone, Study Suggests

Nearly a third of middle-aged Americans regularly take a baby aspirin in the hope of preventing a heart attack or a stroke or lowering their cancer risk. But new research shows that aspirin is not for everyone, and that in some patients this so-called wonder drug is doing more harm than good.

?I stop a lot more aspirin than I start,? said Dr. Alison Bailey, director of the cardiac rehabilitation program at the Gill Heart Institute at the University of Kentucky. ?People don?t even consider aspirin a medicine, or consider that you can have side effects from it. That?s the most challenging part of aspirin therapy.?

Last week, researchers in London reported in the Archives of Internal Medicine that they had analyzed nine randomized studies of aspirin use in the United States, Europe and Japan that included more than 100,000 participants. The study subjects had never had a heart attack or stroke; all regularly took aspirin or a placebo to determine whether aspirin benefits people who have no established heart disease.

In the combined analysis, the researchers found that regular aspirin users were 10 percent less likely than the others to have any type of heart event, and 20 percent less likely to have a nonfatal heart attack. While that sounds like good news, the study showed that the risks of regular aspirin outweighed the benefits.

Aspirin users were about 30 percent more likely to have a serious gastrointestinal bleeding event, a side effect of frequent aspirin use. The overall risk of dying during the study was the same among the aspirin users and the others. And though some previous studies suggested that regular aspirin use could prevent cancer, the new analysis showed no such benefit.

Over all, for every 162 people who took aspirin, the drug prevented one nonfatal heart attack, but caused about two serious bleeding episodes.

?We have been able to show quite convincingly that in people without a previous heart attack or stroke, regular use of aspirin may be more harmful than it is beneficial,? said Dr. Sreenivasa Seshasai of the Cardiovascular Sciences Research Center at St. George?s, University of London.

The findings are likely to add to the confusion about who should regularly take aspirin and who should not.

Research shows that among men who have had a heart attack, regular aspirin use can be lifesaving, lowering the risk of a second heart event by 20 to 30 percent. It also reduces the risk of a recurrence among women who have had a stroke caused by a blood clot.

Aspirin works by interfering with the blood?s clotting action. In blood vessels narrowed by heart disease, fatty deposits can burst, leading to the quick formation of a clot that blocks the flow of blood to the heart or brain. Regularly taking an aspirin helps prevent the clot from forming.

In 2007, the United States Agency for Healthcare Research and Quality reported that 19 percent of Americans regularly took aspirin, including 27 percent of those ages 45 to 64 and about half of those 65 and older.

Yet many current aspirin users have never had a heart attack or stroke, and take aspirin in the hope of preventing one. Among middle-aged aspirin users, the 2007 report found, 23 percent didn?t have established heart disease. Among older aspirin users, 41 percent didn?t have a history of heart disease or stroke.

For people without heart disease, guidelines from the United States Preventive Services Task Force and other national groups say aspirin therapy should be decided case by case, depending on the individual?s risk factors and family history.

But Dr. Seshasai said the new findings didn?t necessarily mean that healthy men and women should immediately stop taking aspirin. People with a strong family history of heart attack or stroke may benefit by continuing the regimen, and they should raise the question with their doctors.

?The decision to treat such individuals with aspirin should be made on a case-by-case basis, taking into account the likely risk of heart attack or stroke in the future,? he said. ?However, as the risk of major bleeding episodes increases proportionately with an increase in benefit, physicians and patients must make carefully considered choices regarding long-term aspirin treatment.?

But some experts say the problem is that not every doctor has caught up with the latest science, and many patients decide on their own to take aspirin.

?They hear aspirin is good, so they take an aspirin,? Dr. Bailey said. ?They don?t think of it as something that could potentially cause harm.?

Source: http://feeds.nytimes.com/click.phdo?i=6d0b10cc5bb2e3eeab5d33ca80efb90d

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OReillyMedia: Crazy-great viz of WTF (Wikipedia, Twitter, Facebook) generation realizing Wiki is dark today. #SOPA http://t.co/EZcU2acN

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Crazy-great viz of WTF (Wikipedia, Twitter, Facebook) generation realizing Wiki is dark today. #SOPA oreil.ly/wTmAot Il y a environ 3 heures via HootSuite Retweeted by 23 people

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iloubnan: #Syria: #Russia opposes sanctions and troops' deployment http://t.co/tTxnhvrT

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#Syria: #Russia opposes sanctions and troops' deployment shar.es/WBPUQ Il y a environ 5 heures via Tweet Button

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A Bit Of Friendly Guidance Concerning Investing In Real Estate In ...

I have worked in the real estate field for quite a few years and since I have a great deal of practical knowledge and experience in this field from time to time friends and family will come to me for advice. A friend of mine not long ago approached me asking my suggestions regarding buying real estate in a different country. This is not one of my areas of expertise nevertheless what I did tell them to do was get online and begin doing a bit of research. Find out everything you are able to regarding the location you?re considering buying property in, not only the general location but additionally the development itself if feasible.

My friend has always enjoyed visiting Mexico and once they started researching houses on the market in the Puerto Vallarta area they happened upon a development called Puerto Bahia Villas. So they took my advice and dug deeper, doing an on-line search for Puerto Bahia Villas reviews to ensure that they could see whether other individuals have submitted their opinions regarding this development on the web. The results that emerged in the search engines have plenty of pictures of beautiful buildings and beautiful shots of the ocean and so on in addition to descriptions of all the amenities and things to do within the area.

Just after digging a little deeper my friend located a Puerto Bahia ripoff report post that was a little distressing. Ripoffreport.com is a website in which individuals can visit and voice their particular issues about a specific product, service or business. The person who left the post states that the owner of the development secured the land unlawfully, saying that the land was taken illegally to be able to reconcile a $100,000 loan given to a local woman who was not in a position to pay it off. I don?t have any way of knowing for sure if the report is true but it would definitely give me second thoughts when it comes to investing money in that development.

This friend chose to keep searching and do a little of additional searching and it wasn?t easy to locate a great deal of reliable evaluations. The majority of the results that appear within the search engines are sites which are talking about all the wonderful attributes of the development. However, after looking a little longer my friend did come across some Puerto Bahia complaints from a few other individuals and he has chosen to search somewhere else and perhaps invest in an alternative nearby neighborhood. My friend also thanked me for the guidance to carry out research cautiously and to keep looking after the initial search made the development look like it might be a good location to invest in.

You can follow any responses to this entry through the RSS 2.0 Responses are currently closed, but you can trackback.

Source: http://36stairsfilm.com/2012/01/a-bit-of-friendly-guidance-concerning-investing-in-real-estate-in-another-country-saved-a-friend-from-making-a-big-blunder/

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Are Physical Constants Really Constant?

Image: Courtesy of Wolfgang Steffen Instituto de Astronom?a, UNAM and Cosmovisi?n

In Brief

• Physicists routinely assume that quantities such as the speed of light are constant: they have the same values everywhere in space and time.
• The authors and their collaborators have called that assumption into question. By comparing quasar observations with laboratory reference measurements, they have argued that chemical elements in different regions of the universe may be absorbing light differently than the same elements on Earth. The data suggest that one of the constants, known as the fine-structure constant, drifts gradually by a few parts per million across the entire observable universe.
• Small though it might seem, this change, if confirmed, would be revolutionary. It could be a sign that space has extra dimensions.

Some things never change. physicists call them the constants of nature. Such quantities as the velocity of light, c, Newton?s constant of gravitation, G, and the mass of the electron, m_e, are assumed to be the same at all places and times in the universe. They form the scaffolding around which the theories of physics are erected, and they define the fabric of our universe. Physics has progressed by making ever more accurate measurements of their values.

And yet, remarkably, no one has ever successfully predicted or explained any of the constants. Physicists have no idea why constants take the special numerical values that they do (given the choice of units). In SI units, c is 299,792,458; G is 6.673 ? 10^?11; and m_e is 9.10938188 ? 10?31?numbers that follow no discernible pattern. The only thread running through the values is that if many of them were even slightly different, complex atomic structures such as living beings would not be possible. The desire to explain the constants has been one of the driving forces behind efforts to develop a complete unified description of nature, or ?theory of everything.? Physicists have hoped that such a theory would show that each of the constants of nature could have only one logically possible value. It would reveal an underlying order to the seeming arbitrariness of nature.

In recent years, however, the status of the constants has grown more muddied, not less. Researchers have found that the best candidate for a theory of everything, the variant of string theory called M-theory, is self-consistent only if the universe has more than four dimensions of space and time?as many as seven more. One? implication is that the constants weobserve may not, in fact, be the truly fundamental ones. Those live in the full higher-dimensional space, and we see only their three-dimensional ?shadows.?

Meanwhile physicists have also come to appreciate that the values of many of the constants may be the result of mere happenstance, acquired during random events and elementary particle processes early in the history of the universe. In fact, string theory allows for a vast number?10⁵⁰⁰?of possible ?worlds? with different self-consistent sets of laws and ?con-
?stants. So far researchers have no idea why our combination was selected. Continued study may reduce the number of logically possible worlds to one, but we have to remain open to the unnerving possibility that our known universe is but one of many?a part of a multiverse?and that different parts of the multiverse exhibit different solutions to the theory, our observed laws of nature being merely one edition of many systems of local bylaws.

No further explanation would then be possible for many of our numerical constants other than that they constitute a rare combination that permits consciousness to evolve. Our observable ?uni?verse could be one of many isolated oases surrounded by an infinity of lifeless space?a surreal place where different forces of nature hold sway and particles such as electrons or structures such as carbon atoms and DNA molecules could be impossibilities. If you tried to venture into that outside world, you would cease to be.

Thus, string theory gives with the right hand and takes with the left. It was devised in part to explain the seemingly arbitrary values of the physical constants, and the basic equations of the theory contain few arbitrary parameters. Yet so far string theory offers no explanation for the observed values of the constants.

A Ruler You Can Trust
indeed, the word ?constant? may be a misnomer. Our constants could vary both in time and in space. If the extra dimensions of space were to change in size, the ?constants? in our three-dimensional world would change with them. If we looked far enough out in space, we might begin to see regions where the ?constants? have settled into different values. Ever since the 1930s researchers have speculated that the constants may not be constant. String theory gives this idea a theoretical plausibility and makes it all the more important for observers to search for deviations from constancy.

Source: http://rss.sciam.com/click.phdo?i=66a56dabb68836e25dfa917da6747544

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UFC 142 picks, Vegas-style: Bettors pounding Vitor Belfort

The debate has raged all day - how will Anthony Johnson's weight snafu affect his fight against Vitor Belfort? The pulse in the betting world is that Johnson is in big trouble at UFC 142 in Rio de Janeiro.

[Don't miss the action: Watch UFC 142 live on Y! Sports]

Belfort's number has jumped 40 cents since it was announced Johnson couldn't make the 186-pound weight limit at middleweight. He actually stepped on the scales yesterday in Rio de Janeiro at 197 pounds. A stipulation was also put in place that Johnson couldn't replenish his body beyond 205 pounds for another weigh-in earlier today.

If you liked Aldo early in the week at minus-220, you missed your chance. There's been heavy fight day steam on Aldo pushing him to minus-275.

Listen to Yahoo! Sports Kevin Iole, Adam Hill from the Las Vegas-Review Journal give out picks for the top fights on the card during last night's "MMA Insiders" show on ESPN1100/98.9 FM in Las Vegas.

UFC 142 betting odds:
Best plays in bold

Chad Mendes (+225) vs. Jose Aldo (-275)
Vitor Belfort (-140) vs. Anthony Johnson (+110)
?????Carlo Prater (+425) vs. Erick Silva (-550)
Terry Etim (+245) vs. Edson Barboza (+290)
Mike Massenzio (+415) vs. Rousimar Palhares (-525)
Sam Stout (+105) vs. Thiago Tavares (-125)
Michihiro Omigawa (+180) vs. Yuri Alcantara (-220)
Gabriel Gonzaga (-120) vs.Edinaldo Oliveira (+100)
Antonio Carvalho (-190) vs. Felipe Arantes (+165)
Ricardo Funch (+380) vs. Mike Pyle (-475)

Source: http://sports.yahoo.com/blogs/mma-cagewriter/ufc-142-picks-vegas-style-bettors-pounding-vitor-215641064.html

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Watching Giant Killer Waves Swallow Surfers in Slow Motion Scares the Dude Out of Me [Video]

Chris Bryan, the amazing slow motion videographer, used a Phantom camera to capture surfers riding humungous waves in Teahupo?o, Tahiti in super slow motion. It's terrifying to see the sea monster known as the ocean so huge and intimidating and hungry. Seriously, the waves were so big the day Bryan filmed the French Navy issued a double code red warning and threatened to arrest people that went into the ocean. More »

Source: http://feeds.gawker.com/~r/gizmodo/full/~3/hG2UQ-eM8Us/watching-giant-killer-waves-swallow-surfers-in-slow-motion-scares-the-dude-out-of-me

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Paula Deen Can't Eat Own Dishes Due to Diabetes

The Food Network's Paula Deen is about to come clean with an ironic, sad admission: She can’t eat her own dishes anymore because she has diabetes.

The Georgia-born chef, considered the queen of high-calorie, Southern comfort food who has five best-selling cookbooks, has never addressed this.

In fact, she has been trying to keep her condition a secret, even after the National Enquirer reported in April 2011 that she has Type 2 diabetes.

Type 2 diabetes has often been associated with fatty foods and obesity.

Neither Paula Deen, 64, nor her reps have confirmed this report.

If Paula's brand is hurt by this revelation, she's covering her bases.

Sources say Deen has hammered out a seven-figure deal to be the spokeswoman pharmaceutical company Novartis, endorsing the drug she is taking.

Makes sense. But repositioning herself may prove a tough task.

“Paula Deen is going to have to rebrand herself now that she has diabetes,” said a source. “She’s going to have to start cooking healthier recipes."

"She can’t keep pushing mac and cheese and deep-fried Twinkies when she is hawking a diabetes drug five minutes later.”

In August, No Reservations host Anthony Bourdain called Deen “the worst, most dangerous person to America” and said she should “think twice before telling an already obese nation that it’s OK to eat food that is killing us.”

Never one to mince words, Anthony Bourdain.

Source: http://www.thehollywoodgossip.com/2012/01/paula-deen-cant-eat-own-dishes-due-to-diabetes/

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